Riley is a fun 11-year-old girl who must face major changes in her life when her parents decide to leave her hometown of Minnesota to live in San Francisco. Within Riley’s brain, several different emotions coexist, such as Joy, Fear, Anger, Littleton, and Sadness. Their leader is Joy, who strives hard to make Riley’s life always happy. However, a confusion in the control room causes her and Sadness to be thrown out. Now they need to go through the various islands in Riley’s thoughts so they can return to the control room – and while that does not happen, the girl’s life changes radically.